Goldbaum MH, Sample PA, Chan K, Williams J, Lee TW, Blumenthal E, Girkin CA, Zangwill LM, Bowd C, Sejnowski T, Weinreb RN.

Invest Ophthalmol Vis Sci. 2002 Jan;43(1):162-9.
Ophthalmic Informatics Laboratory, Department of Ophthalmology, University of California at San Diego, La Jolla, California, USA. mgoldbaum@ucsd.edu

ABSTRACT:

PURPOSE: To determine which machine learning classifier learns best to interpret standard automated perimetry (SAP) and to compare the best of the machine classifiers with the global indices of STATPAC 2 and with experts in glaucoma.

METHODS: Multilayer perceptrons (MLP), support vector machines (SVM), mixture of Gaussian (MoG), and mixture of generalized Gaussian (MGG) classifiers were trained and tested by cross validation on the numerical plot of absolute sensitivity plus age of 189 normal eyes and 156 glaucomatous eyes, designated as such by the appearance of the optic nerve. The authors compared performance of these classifiers with the global indices of STATPAC, using the area under the ROC curve. Two human experts were judged against the machine classifiers and the global indices by plotting their sensitivity-specificity pairs.

RESULTS: MoG had the greatest area under the ROC curve of the machine classifiers. Pattern SD (PSD) and corrected PSD (CPSD) had the largest areas under the curve of the global indices. MoG had significantly greater ROC area than PSD and CPSD. Human experts were not better at classifying visual fields than the machine classifiers or the global indices.

CONCLUSIONS: MoG, using the entire visual field and age for input, interpreted SAP better than the global indices of STATPAC. Machine classifiers may augment the global indices of STATPAC.

Article as Full-Text PDF

Figure from this article:

Glaucoma & Cataract:
www.glaucoma.org.il

Surgery

Diagnosis

This website was written by Prof. Eytan Blumenthal, to better understand glaucoma & cataract. This information should not replace medical consultation.

Related Posts

Risk Factors and Incidence of Ocular Hypertension After Penetrating Keratoplasty
Faik Oruc¸oglu, MD, Eytan Z. Blumenthal, MD, Joseph Frucht-Pery, MD, and Abraham Solomon, MD Journal of Glaucoma. 2013 Feb 19. Kudret Eye Hospital, Istanbul, Turkey Department of Ophthalmology, Hadassah-Hebrew...
List of Publications- by Prof. Eytan Blumenthal
ORIGINAL RESEARCH PAPERS Blumenthal EZ. Adjusting the slit-lamp oculars: An unnecessary burden or a must?  Survey of Ophthalmology 1995;40(3):225-228. Abstract Full-text (PDF) Blumenthal EZ, Serpetopoulos...
Adjusting The Slit-Lamp Oculars: An Unnecessary Burden Or A Must?
Blumenthal EZ. Surv Ophthalmol. 1995 Nov-Dec;40(3):225-8. Department of Opthalmology, Hadassah University Hospital, Jerusalem, Israel. ABSTRACT: Adjusting the slit-lamp eyepiece rings is perceived by some...
On Focusing The Slit-Lamp: Part I. An Inaccurate Ocular Setting--What Is There To Lose?
Blumenthal EZ, Serpetopoulos CN. Surv Ophthalmol. 1998 Jan-Feb;42(4):351-4. Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel. ABSTRACT: Adjustments of the diopter rings on the...
Early Transient Visual Acuity Loss After Lasik Due To Steroid-Induced Elevation Of Intraocular Pressure
Frucht-Pery J, Landau D, Raiskup F, Orucov F, Strassman E, Blumenthal EZ, Solomon A. J Refract Surg. 2007 Mar;23(3):244-51. Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem,...